Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs

P. Valenzuela, M. Quiroga, J. Zaldivar, W. J. Rutter, M. W. Kirschner, D. W. Cleveland

Research output: Contribution to journalArticlepeer-review

237 Citations (Scopus)

Abstract

Most of the mRNA sequences coding for α and β tubulin in embryonic chick brain have been determined by sequencing of cloned cDNA copies of these mRNAs. From a 1,682-base pair cDNA sequence we have deduced the entire protein sequence for β tubulin. For α tubulin, all but about 38 N-terminal amino acids have been deduced from the cDNA sequence. Although tyrosine has previously been shown to be post-translationally added to the C-terminus of α tubulin by a specific ligase, we conclude that the primary post-translational event must be the removal, not the addition, of tyrosine because a terminal tyrosine is encoded by the mRNA.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalNature
Volume289
Issue number5799
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Medicine(all)
  • General

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