TY - JOUR
T1 - Novel evidence on sepsis-inducing pathogens
T2 - from laboratory to bedside
AU - Gatica, Sebastian
AU - Fuentes, Brandon
AU - Rivera-Asín, Elizabeth
AU - Ramírez-Céspedes, Paula
AU - Sepúlveda-Alfaro, Javiera
AU - Catalán, Eduardo A.
AU - Bueno, Susan M.
AU - Kalergis, Alexis M.
AU - Simon, Felipe
AU - Riedel, Claudia A.
AU - Melo-Gonzalez, Felipe
N1 - Publisher Copyright:
Copyright © 2023 Gatica, Fuentes, Rivera-Asín, Ramírez-Céspedes, Sepúlveda-Alfaro, Catalán, Bueno, Kalergis, Simon, Riedel and Melo-Gonzalez.
PY - 2023
Y1 - 2023
N2 - Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis.
AB - Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis.
KW - diagnostics
KW - immunology
KW - inflammation
KW - microorganisms
KW - prognosis
KW - sepsis
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85164606818&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2023.1198200
DO - 10.3389/fmicb.2023.1198200
M3 - Review article
AN - SCOPUS:85164606818
SN - 1664-302X
VL - 14
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 1198200
ER -