Non-abortive effect of Adhatoda vasica spissum leaf extract by oral administration in rats

R. Burgos, M. Forcelledo, H. Wagner, A. Müller, J. Hancke, G. Wikman, H. Croxatto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The possible abortive effect of an extract of Adhatoda vasica leaf spissum, was studied in rats. The principal alkaloid detected in the extract was vasicine (0.85 ±0.03%). The extract (325 mg/kg/day) was administered with a gastric cannula to a group of 5 pregnant females between day 1 and 9 of pregnancy. In another experiment 9 pregnant females received in the water 0.25 and 2.5% of Adhatoda vasica between day 1 and 9 of pregnancy. It was concluded that the administration of Adhatoda vasica did not produce abortion in any of the treated groups.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalPhytomedicine
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1997

Keywords

  • Abortive effect
  • Adhatoda vasica
  • Rats
  • Vasicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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