New Evidence on BPA’s Role in Adipose Tissue Development of Proinflammatory Processes and Its Relationship with Obesity

Jorge Enrique González-Casanova, Valmore Bermúdez, Nelson Javier Caro Fuentes, Lissé Chiquinquirá Angarita, Nelson Hernando Caicedo, Jocelyn Rivas Muñoz, Diana Marcela Rojas-Gómez

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Bisphenol A (BPA) is a xenobiotic with endocrine disruptor properties which interacts with various receptors, eliciting a cellular response. In the plastic industry, BPA is widely used in the production of polycarbonate and epoxy-phenolic resins to provide elastic properties. It can be found in the lining of canned foods, certain plastic containers, thermal printing papers, composite dental fillings, and medical devices, among other things. Therefore, it is a compound that, directly or indirectly, is in daily contact with the human organism. BPA is postulated to be a factor responsible for the global epidemic of obesity and non-communicable chronic diseases, belonging to the obesogenic and diabetogenic group of compounds. Hence, this endocrine disruptor may be responsible for the development of metabolic disorders, promoting in fat cells an increase in proinflammatory pathways and upregulating the expression and release of certain cytokines, such as IL6, IL1β, and TNFα. These, in turn, at a systemic and local level, are associated with a chronic low-grade inflammatory state, which allows the perpetuation of the typical physiological complications of obesity.

Original languageEnglish
Article number8231
JournalInternational Journal of Molecular Sciences
Volume24
Issue number9
DOIs
Publication statusPublished - May 2023

Keywords

  • adipose tissue
  • bisphenol A
  • endocrine disruptor
  • inflammation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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