Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat

W. I. Silva; H. F. Miranda; W. W. Wolstenholme; N. Cuevas; A. Ucros

doi:10.1016/0143-4179(88)90068-6

Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat

W. I. Silva, H. F. Miranda, W. W. Wolstenholme, N. Cuevas, A. Ucros

Medicine School

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC₅₀ of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC₅₀ values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4-740 nM SP resulted in a decrease in the EC₅₀ and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC₅₀ and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Neuropeptides
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0143-4179(88)90068-6
Publication status	Published - 1988

ASJC Scopus subject areas

Biochemistry
Endocrinology
Endocrinology, Diabetes and Metabolism
Clinical Neurology
Neuroscience(all)
Cellular and Molecular Neuroscience
Endocrine and Autonomic Systems
Neurology
Medicine(all)

UN SDGs

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title = "Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat",

abstract = "The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4-740 nM SP resulted in a decrease in the EC50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.",

author = "Silva, {W. I.} and Miranda, {H. F.} and Wolstenholme, {W. W.} and N. Cuevas and A. Ucros",

year = "1988",

doi = "10.1016/0143-4179(88)90068-6",

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T1 - Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat

AU - Silva, W. I.

AU - Miranda, H. F.

AU - Wolstenholme, W. W.

AU - Cuevas, N.

AU - Ucros, A.

PY - 1988

Y1 - 1988

N2 - The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4-740 nM SP resulted in a decrease in the EC50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.

AB - The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4-740 nM SP resulted in a decrease in the EC50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.

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AN - SCOPUS:0023886857

VL - 11

SP - 153

EP - 157

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 4

ER -

Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat

Abstract

ASJC Scopus subject areas

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