Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

Hugo González, Daniela Elgueta, Andro Montoya, Rodrigo Pacheco

Research output: Contribution to journalReview articlepeer-review

203 Citations (SciVal)

Abstract

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Neuroimmunology
Volume274
Issue number1-2
DOIs
Publication statusPublished - 2014

Keywords

  • Blood-brain barrier
  • Microglia
  • Neo-antigens
  • Neurodegenerative disorders
  • Neuroinflammation
  • T-cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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