Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.
|Number of pages
|Research Communications in Substances of Abuse
|Published - 1984
ASJC Scopus subject areas
- Medicine (miscellaneous)