Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches

Julian Bejarano, Mario Navarro-Marquez, Francisco Morales-Zavala, Javier O. Morales, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Yvo Flores, Hugo E. Verdejo, Pablo F. Castro, Sergio Lavandero, Marcelo J. Kogan

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease. This review focuses on the development of nanosystems for therapy and diagnosis of subclinical atherosclerosis, coronary artery disease, and myocardial infarction and the evolution of nanosystems as theranostic tools. We also discuss the use of nanoparticles in noninvasive imaging, targeted drug delivery, photothermal therapies together with the challenges faced by nanosystems during clinical translation.

Original languageEnglish
Pages (from-to)4710-4732
Number of pages23
JournalTheranostics
Volume8
Issue number17
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Atherosclerosis
  • Cardiovascular diseases
  • Myocardial infarction
  • Nanoparticles
  • Theranostics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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