My journey in the discovery of nucleotide sugar transporters of the Golgi apparatus

Carlos B. Hirschberg

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Defects in protein glycosylation can have a dramatic impact on eukaryotic cells and is associated with mental and developmental pathologies in humans. The studies outlined below illustrate how a basic biochemical problem in the mechanisms of protein glycosylation, specifically substrate transporters of nucleotide sugars, including ATP and 3-phosphoadenyl-5-phosphosulfate (PAPS), in the membrane of the Golgi apparatus and endoplasmic reticulum, expanded into diverse biological systems from mammals, including humans, to yeast, roundworms, and protozoa. Using these diverse model systems allowed my colleagues and me to answer fundamental biological questions that enabled us to formulate far-reaching hypotheses and expanded our knowledge of human diseases caused by malfunctions in the metabolic processes involved.

Original languageEnglish
Pages (from-to)12653-12662
Number of pages10
JournalJournal of Biological Chemistry
Volume293
Issue number33
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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