Multiple levels of epigenetic control for bone biology and pathology

Martin Montecino, Gary Stein, Janet Stein, Kaleem Zaidi, Rodrigo Aguilar

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Multiple dimensions of epigenetic control contribute to regulation of gene expression that governs bone biology and pathology. Once confined to DNA methylation and a limited number of post-translational modifications of histone proteins, the definition of epigenetic mechanisms is expanding to include contributions of non-coding RNAs and mitotic bookmarking, a mechanism for retaining phenotype identity during cell proliferation. Together these different levels of epigenetic control of physiological processes and their perturbations that are associated with compromised gene expression during the onset and progression of disease, have contributed to an unprecedented understanding of the activities (operation) of the genomic landscape. Here, we address general concepts that explain the contribution of epigenetic control to the dynamic regulation of gene expression during eukaryotic transcription. This article is part of a Special Issue entitled Epigenetics and Bone.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalBone
Volume81
DOIs
Publication statusPublished - 13 Mar 2015

Keywords

  • DNA methylation
  • Histone modifications
  • Intanuclear domains
  • Mitotic bookmarking
  • RUNX2 epigenetics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Physiology

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