Multimorbidity and 11-year mortality in adults: a prospective analysis using the Chilean National Health Survey

Gabriela Nazar, Felipe Díaz-Toro, Fanny Petermann-Rocha, Fabián Lanuza, Claudia Troncoso, Ana María Leiva-Ordóñez, Yeny Concha-Cisternas, Carlos Celis-Morales

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Research on morbidity and mortality often emphasizes individual diseases over the cumulative effects of multimorbidity, especially in low- and middle-income countries. This study aimed to analyze the association between multimorbidity and all-cause mortality in a representative sample of the Chilean population. This longitudinal study used data from 3701 subjects aged ≥15 years who participated in the Chilean National Health Survey conducted between 2009 and 2010. We included 16 self-reported highly prevalent morbidities. All-cause mortality data from an 11-year follow-up were collected from the Chilean Civil Registry. The Cox proportional hazard model, adjusted for confounders, determined the association between multimorbidity categories and all-cause mortality. Of the total sample, 24.3% reported no morbidity, while 50.4% two or more. After adjustment, participants with four or more morbidities had a 1.66 times higher mortality risk [95% confidence interval (CI): 1.03–2.67] than those without morbidities. The mortality risk increased by 10% for each additional morbidity [HR: 1.09 (CI: 1.04–1.16)]. Multimorbidity was common in the Chilean population and increased the mortality risk, which greatly challenges the health system to provide an integral and coordinated approach to healthcare.

Original languageEnglish
Article numberdaad176
JournalHealth Promotion International
Issue number6
Publication statusPublished - 1 Dec 2023


  • chronic disease
  • morbidity
  • mortality
  • multimorbidity

ASJC Scopus subject areas

  • Health(social science)
  • Public Health, Environmental and Occupational Health


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