MUC1, glycans and the cell-surface barrier to embryo implantation

J. D. Aplin, M. Meseguer, C. Simón, M. E. Ortíz, H. Croxatto, C. J.P. Jones

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MUC1 at the cell surface can inhibit cell adhesion. This raises the possibility of the existence of a uterine barrier to implantation that might allow maternal rejection of poorer quality embryos. To investigate the mechanism of implantation, human embryos were incubated with endometrial epithelial monolayers. Hatched blastocysts were found to attach readily to the epithelial surface. MUC1 was lost from epithelial cells beneath and near to the attached embryo, while normal expression persisted in neighbouring cells.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalBiochemical Society Transactions
Volume29
Issue number2
DOIs
Publication statusPublished - 1 Jan 2001

Keywords

  • Endometrium
  • Mucin
  • Oviduct
  • Primate

ASJC Scopus subject areas

  • Biochemistry

Fingerprint

Dive into the research topics of 'MUC1, glycans and the cell-surface barrier to embryo implantation'. Together they form a unique fingerprint.

Cite this