Motor Skill Training May Restore Impaired Corticospinal Tract Fibers in Children With Cerebral Palsy

Yannick Bleyenheuft, Laurence Dricot, Daniela Ebner-Karestinos, Julie Paradis, Geoffroy Saussez, Anne Renders, Anne De Volder, Rodrigo Araneda, Andrew M. Gordon, Kathleen M. Friel

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background. In children with unilateral cerebral palsy (UCP), the fibers of the corticospinal tract (CST) emerging from the lesioned hemisphere are damaged following the initial brain injury. The extent to which the integrity of these fibers is restorable with training is unknown. Objective. To assess changes in CST integrity in children with UCP following Hand-and-Arm-Bimanual-Intensive-Therapy-Including-Lower-Extremity (HABIT-ILE) compared to a control group. Methods. Forty-four children with UCP participated in this study. Integrity of the CSTs was measured using diffusion tensor imaging before and after 2 weeks of HABIT-ILE (treatment group, n = 23) or 2 weeks apart without intensive treatment (control group, n = 18). Fractional anisotropy (FA) and mean diffusivity (MD) were the endpoints for assessing the integrity of CST. Results. As highlighted in our whole tract analysis, the FA of the CST originating from the nonlesioned and lesioned hemispheres increased significantly after therapy in the treatment group compared to the control group (group * test session interaction: P <.001 and P =.049, respectively). A decrease in MD was also observed in the CST emerging from the nonlesioned and lesioned hemispheres (group * time interaction: both P <.001). In addition, changes in manual ability correlated with changes in FA in both CSTs (r = 0.463, P =.024; r = 0.643, P <.001) and changes in MD in CST emerging from nonlesioned hemisphere (r = −0.662, P <.001). Conclusions. HABIT-ILE improves FA/MD in the CST and hand function of children with UCP, suggesting that CST fibers retain a capacity for functional restoration. This finding supports the application of intensive motor skill training in clinical practice for the benefit of numerous patients.

Original languageEnglish
Pages (from-to)533-546
Number of pages14
JournalNeurorehabilitation and Neural Repair
Volume34
Issue number6
DOIs
Publication statusPublished - 1 Jun 2020
Externally publishedYes

Keywords

  • cerebral palsy
  • corticospinal tract
  • diffusion tensor imaging
  • intensive training
  • motor skill training

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Motor Skill Training May Restore Impaired Corticospinal Tract Fibers in Children With Cerebral Palsy'. Together they form a unique fingerprint.

Cite this