Molecular basis of early stages of Clostridium difficile infection: Germination and colonization

Mahfuzur R. Sarker, Daniel Paredes-Sabja

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Clostridium difficile infections (CDIs) occur when antibiotic therapy disrupts the gastrointestinal flora, favoring infected C. difficile spores to germinate, outgrow, colonize and produce toxins. During CDI, C. difficile vegetative cells initiate the process of sporulation allowing a fraction of the spores to remain adhered to the intestinal surfaces. These spores, which are unaffected by antibiotic therapy commonly used for CDIs, then germinate, outgrow and recolonize the hosts GI tract causing relapse of CDI. Consequently, the germination and colonization processes can be considered as the earliest and most essential steps for the development as well as relapse of CDI. The aim of this review is to provide an overview on the molecular basis involved in C. difficile spore germination and colonization.

Original languageEnglish
Pages (from-to)933-943
Number of pages11
JournalFuture Microbiology
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • CDI germination
  • Clostridium difficile
  • colonization

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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