Modulation of Immune Cells as a Therapy for Cutaneous Lupus Erythematosus

Jorge A. Soto, Felipe Melo-González, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Cutaneous lupus erythematosus (CLE) is an autoimmune disorder like systemic lupus erythematosus (SLE). Both SLE and CLE characterize autoantibody secretion and immune cell recruitment. In particular, CLE can be divided into three more frequent types, varying in the severity of the skin lesions they present. The role of type I IFN was shown to be one of the leading causes of the development of this pathology in the skin. Different treatments have been developed and tested against these different variants of CLE to decrease the increasing levels of CLE in humans. In this article, a literature revision discussing the similarities between SLE and CLE is carried out. In addition, new advances in understanding the development of CLE and the leading treatments being evaluated in animal models and clinical trials are reviewed.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume23
Issue number18
DOIs
Publication statusPublished - 14 Sept 2022

Keywords

  • cutaneous lupus erythematosus
  • immune cells
  • systemic lupus erythematosus
  • treatments

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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