Modulating the function of the immune system by thyroid hormones and thyrotropin

Evelyn L. Jara; Natalia Muñoz-Durango; Carolina Llanos; Carlos Fardella; Pablo A. González; Susan M. Bueno; Alexis M. Kalergis; Claudia A. Riedel

doi:10.1016/j.imlet.2017.02.010

Modulating the function of the immune system by thyroid hormones and thyrotropin

Evelyn L. Jara, Natalia Muñoz-Durango, Carolina Llanos, Carlos Fardella, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Life Sciences School

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

Abstract

Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.

Original language	English
Pages (from-to)	76-83
Number of pages	8
Journal	Immunology Letters
Volume	184
DOIs	https://doi.org/10.1016/j.imlet.2017.02.010
Publication status	Published - 1 Apr 2017

Keywords

Immunity
Inflammation
Thyroid hormones
TSH

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.imlet.2017.02.010

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title = "Modulating the function of the immune system by thyroid hormones and thyrotropin",

abstract = "Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.",

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AU - Jara, Evelyn L.

AU - Muñoz-Durango, Natalia

AU - Llanos, Carolina

AU - Fardella, Carlos

AU - González, Pablo A.

AU - Bueno, Susan M.

AU - Kalergis, Alexis M.

AU - Riedel, Claudia A.

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N2 - Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.

AB - Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.

KW - Immunity

KW - Inflammation

KW - Thyroid hormones

KW - TSH

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JF - Immunology Letters

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Modulating the function of the immune system by thyroid hormones and thyrotropin

Abstract

Keywords

ASJC Scopus subject areas

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