TY - JOUR
T1 - Modulating the function of the immune system by thyroid hormones and thyrotropin
AU - Jara, Evelyn L.
AU - Muñoz-Durango, Natalia
AU - Llanos, Carolina
AU - Fardella, Carlos
AU - González, Pablo A.
AU - Bueno, Susan M.
AU - Kalergis, Alexis M.
AU - Riedel, Claudia A.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.
AB - Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.
KW - Immunity
KW - Inflammation
KW - Thyroid hormones
KW - TSH
UR - http://www.scopus.com/inward/record.url?scp=85014153480&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2017.02.010
DO - 10.1016/j.imlet.2017.02.010
M3 - Review article
AN - SCOPUS:85014153480
SN - 0165-2478
VL - 184
SP - 76
EP - 83
JO - Immunology Letters
JF - Immunology Letters
ER -