Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

Paula I. Rodas, Doris Pérez, Claudia Jauffret, Yaquelin González, Carolina Carreño, Cecilia V. Tapia, Eduardo Osorio, Luis A. Velasquez, Myron Christodoulides

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalJournal of Infectious Diseases
Volume215
Issue number3
DOIs
Publication statusPublished - 2017

Keywords

  • Extracellular matrix
  • Human Fallopian tube epithelial cells
  • Matrix metalloproteinases
  • Neisseria gonorrhoeae

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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