Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

Paula I. Rodas; Doris Pérez; Claudia Jauffret; Yaquelin González; Carolina Carreño; Cecilia V. Tapia; Eduardo Osorio; Luis A. Velasquez; Myron Christodoulides

doi:10.1093/infdis/jiw568

Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

Paula I. Rodas, Doris Pérez, Claudia Jauffret, Yaquelin González, Carolina Carreño, Cecilia V. Tapia, Eduardo Osorio, Luis A. Velasquez, Myron Christodoulides

Medicine School

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

Original language	English
Pages (from-to)	452-455
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	215
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiw568
Publication status	Published - 2017

Keywords

Extracellular matrix
Human Fallopian tube epithelial cells
Matrix metalloproteinases
Neisseria gonorrhoeae

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiw568

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Rodas, P. I., Pérez, D., Jauffret, C., González, Y., Carreño, C., Tapia, C. V., Osorio, E., Velasquez, L. A., & Christodoulides, M. (2017). Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae. Journal of Infectious Diseases, 215(3), 452-455. https://doi.org/10.1093/infdis/jiw568

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title = "Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae",

abstract = "Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.",

keywords = "Extracellular matrix, Human Fallopian tube epithelial cells, Matrix metalloproteinases, Neisseria gonorrhoeae",

author = "Rodas, {Paula I.} and Doris P{\'e}rez and Claudia Jauffret and Yaquelin Gonz{\'a}lez and Carolina Carre{\~n}o and Tapia, {Cecilia V.} and Eduardo Osorio and Velasquez, {Luis A.} and Myron Christodoulides",

note = "Publisher Copyright: {\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society.",

year = "2017",

doi = "10.1093/infdis/jiw568",

language = "English",

volume = "215",

pages = "452--455",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

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Rodas, PI, Pérez, D, Jauffret, C, González, Y, Carreño, C, Tapia, CV, Osorio, E, Velasquez, LA & Christodoulides, M 2017, 'Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae', Journal of Infectious Diseases, vol. 215, no. 3, pp. 452-455. https://doi.org/10.1093/infdis/jiw568

TY - JOUR

T1 - Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

AU - Rodas, Paula I.

AU - Pérez, Doris

AU - Jauffret, Claudia

AU - González, Yaquelin

AU - Carreño, Carolina

AU - Tapia, Cecilia V.

AU - Osorio, Eduardo

AU - Velasquez, Luis A.

AU - Christodoulides, Myron

PY - 2017

Y1 - 2017

N2 - Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

AB - Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

KW - Extracellular matrix

KW - Human Fallopian tube epithelial cells

KW - Matrix metalloproteinases

KW - Neisseria gonorrhoeae

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U2 - 10.1093/infdis/jiw568

DO - 10.1093/infdis/jiw568

M3 - Article

AN - SCOPUS:85019855824

SN - 0022-1899

VL - 215

SP - 452

EP - 455

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

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ASJC Scopus subject areas

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