Modeling cell decisions in bone formation

Rodrigo Assar, Alejandro Maass, Joaquín Fernández, Ernesto Kofman, Martín A. Montecino

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The process of bone formation involves several mechanisms, which can manifest dysfunctions such as osteoporosis in case of imbalances between them. In basic terms, osteo-adipo progenitors derive from the bone marrow, and depending on multiple stimulus signals, can stay in their progenitor state (preosteoblast) or can differentiate to form bone and fat tissue [3].We point to model the dynamics of the cell decisions to differentiate from preosteoblasts to osteoblasts, considering stimulatory signals, and the important role of epigenetics. Given a cell, the presence of specific epigenetic marks favors the expression of biomarker genes and the posterior differentiation into osteoblasts. Starting with a group of marked cells, we model in silico the proliferation of such cells and the epigenetic inheritance. We consider a hybrid system [2, 8] in which each cell grows continuously over time until being ready to divide, and the success in division and epigenetic inheritance includes randomness. Stimulating the proliferation of marked cells, the model predicts the dynamics to increase the number of osteoblasts helping in testing medical treatments and production in vitro.

Original languageEnglish
Title of host publicationAnalysis, Modelling, Optimization, and Numerical Techniques, ICAMI 2013
EditorsGerard Olivar Tost, Olga Vasilieva
PublisherSpringer New York LLC
Pages235-245
Number of pages11
ISBN (Print)9783319125824
DOIs
Publication statusPublished - 2015
Event2nd International Conference on Applied Mathematics and Informatics, ICAMI 2013 - San Andres Island, United States
Duration: 24 Nov 201329 Nov 2013

Publication series

NameSpringer Proceedings in Mathematics and Statistics
Volume121
ISSN (Print)2194-1009
ISSN (Electronic)2194-1017

Other

Other2nd International Conference on Applied Mathematics and Informatics, ICAMI 2013
CountryUnited States
CitySan Andres Island
Period24/11/1329/11/13

Keywords

  • Bone formation
  • Cell decisions
  • Hybrid systems

ASJC Scopus subject areas

  • Mathematics(all)

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  • Cite this

    Assar, R., Maass, A., Fernández, J., Kofman, E., & Montecino, M. A. (2015). Modeling cell decisions in bone formation. In G. O. Tost, & O. Vasilieva (Eds.), Analysis, Modelling, Optimization, and Numerical Techniques, ICAMI 2013 (pp. 235-245). (Springer Proceedings in Mathematics and Statistics; Vol. 121). Springer New York LLC. https://doi.org/10.1007/978-3-319-12583-1_16