Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens

Hugo F. Miranda; Guido E. Santacana; Wayne W. Wolstenholme; Gil M. Moreu

doi:10.1016/0306-3623(87)90038-3

Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens

Hugo F. Miranda, Guido E. Santacana, Wayne W. Wolstenholme, Gil M. Moreu

Medicine School

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M₁-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M₂-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.

Original language	English
Pages (from-to)	643-645
Number of pages	3
Journal	General Pharmacology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/0306-3623(87)90038-3
Publication status	Published - 1987

ASJC Scopus subject areas

Pharmacology

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title = "Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens",

abstract = "1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M1-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M2-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.",

author = "Miranda, {Hugo F.} and Santacana, {Guido E.} and Wolstenholme, {Wayne W.} and Moreu, {Gil M.}",

year = "1987",

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T1 - Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens

AU - Miranda, Hugo F.

AU - Santacana, Guido E.

AU - Wolstenholme, Wayne W.

AU - Moreu, Gil M.

PY - 1987

Y1 - 1987

N2 - 1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M1-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M2-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.

AB - 1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M1-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M2-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.

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U2 - 10.1016/0306-3623(87)90038-3

DO - 10.1016/0306-3623(87)90038-3

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AN - SCOPUS:0023265040

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JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 6

ER -

Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens

Abstract

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