Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens

Hugo F. Miranda, Guido E. Santacana, Wayne W. Wolstenholme, Gil M. Moreu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M1-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M2-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalGeneral Pharmacology
Volume18
Issue number6
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Pharmacology

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