Mild hypothermia attenuates lung edema and plasma interleukin-1β in a rat mechanical ventilation-induced lung injury model

Pablo Cruces, Ricardo Ronco, Benjamín Erranz, Paulette Conget, Cristóbal Carvajal, Alejandro Donoso, Franco Daz

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Recent data suggest that deep hypothermia has protective effects on experimental induced lung injury. It is not well known if these effects persist with mild hypothermia. The authors hypothesized that mild hypothermia may attenuate lung injury and decrease local and systemic proinflammatory cytokines in a rat model of injurious mechanical ventilation (MV). Twelve Sprague-Dawley male adult rats were anesthetized, intubated, and randomly allocated to normothermia group (37°C) (NT) or mild hypothermia group (34°C) (MH). After 2 hours of deleterious MV (peak inspiratory pressure [PIP] 40 cm H2O, zero end-expiratory pressure [ZEEP], and inspiratory fraction of oxygen [Fio2] 100%), arterial blood gases, lung gravimetry, and histological study were obtained. Protein content, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α were measured in plasma and bronchoalveolar lavage (BAL) fluid. Subjects that underwent MH had a significant lower wet-to-dry lung weight ratio (8.32 ± 0.28 vs. 10.8 ± 0.49, P = .01), IL-1β plasma concentration (0.6 ± 0.6 vs. 10.27 ± 2.80 pg/mL, P = .0048) and Paco2. There were no differences in terms of Pao2, histological injury, or BAL protein content. In this model of injurious mechanical ventilation, subjects treated with mild hypothermia had less lung edema and lower plasma IL-1β. Some of known beneficial effects of deep hypothermia can be obtained with mild hypothermia.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalExperimental Lung Research
Volume37
Issue number9
DOIs
Publication statusPublished - 1 Nov 2011

Keywords

  • therapeutic hypothermia
  • ventilator-induced lung injury

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Mild hypothermia attenuates lung edema and plasma interleukin-1β in a rat mechanical ventilation-induced lung injury model'. Together they form a unique fingerprint.

Cite this