Abstract
The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.
| Original language | English |
|---|---|
| Pages (from-to) | 1859-1864 |
| Number of pages | 6 |
| Journal | Natural Product Communications |
| Volume | 5 |
| Issue number | 12 |
| Publication status | Published - 2010 |
Keywords
- Biotransformation
- Laurencia claviformis
- Mucor plumbeus
- Pacifenol
- Pacifidiene
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Plant Science
- Complementary and alternative medicine