Microbial transformation of marine halogenated sesquiterpenes

Aurelio San Martin, Juana Rovirosa, Alvaro Carrasco, Silvia Orejarena, Jorge Soto-Delgado, Renato Contreras, M. Cristina Chamy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.

Original languageEnglish
Pages (from-to)1859-1864
Number of pages6
JournalNatural Product Communications
Issue number12
Publication statusPublished - 2010


  • Biotransformation
  • Laurencia claviformis
  • Mucor plumbeus
  • Pacifenol
  • Pacifidiene

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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