Metal resistance in acidophilic microorganisms and its significance for biotechnologies

Mark Dopson, David S. Holmes

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)

Abstract

Extremely acidophilic microorganisms have an optimal pH of <3 and are found in all three domains of life. As metals are more soluble at acid pH, acidophiles are often challenged by very high metal concentrations. Acidophiles are metal-tolerant by both intrinsic, passive mechanisms as well as active systems. Passive mechanisms include an internal positive membrane potential that creates a chemiosmotic gradient against which metal cations must move, as well as the formation of metal sulfate complexes reducing the concentration of the free metal ion. Active systems include efflux proteins that pump metals out of the cytoplasm and conversion of the metal to a less toxic form. Acidophiles are exploited in a number of biotechnologies including biomining for sulfide mineral dissolution, biosulfidogenesis to produce sulfide that can selectively precipitate metals from process streams, treatment of acid mine drainage, and bioremediation of acidic metal-contaminated milieux. This review describes how acidophilic microorganisms tolerate extremely high metal concentrations in biotechnological processes and identifies areas of future work that hold promise for improving the efficiency of these applications.

Original languageEnglish
Pages (from-to)8133-8144
Number of pages12
JournalApplied Microbiology and Biotechnology
Volume98
Issue number19
DOIs
Publication statusPublished - 2014

Keywords

  • Biomining
  • Biooxidation
  • Database
  • Homeostasis
  • Metagenome
  • System biology

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Fingerprint

Dive into the research topics of 'Metal resistance in acidophilic microorganisms and its significance for biotechnologies'. Together they form a unique fingerprint.

Cite this