Lysosome motility and distribution: Relevance in health and disease

Juan Esteban Oyarzún, Jonathan Lagos, Mary Carmen Vázquez, Cristian Valls, Catalina De la Fuente, María Isabel Yuseff, Alejandra R. Alvarez, Silvana Zanlungo

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Lysosomes are dynamic organelles, which can fuse with a variety of targets and undergo constant regeneration. They can move along microtubules in a retrograde and anterograde fashion by using motor proteins, kinesin and dynein, being main players in extracellular secretion, intracellular components degradation and recycling. Moreover, lysosomes interact with other intracellular organelles to regulate their turnover, such as ER, mitochondria and peroxisomes. The correct localization of lysosomes is relevant in several physiological processes, including appropriate antigen presentation, neurotransmission and receptors modulation in neuronal synapsis, whereas hepatic lysosomes and autophagy are master regulators of nutrient homeostasis. Alterations in lysosome function due to mutation of genes encoding lysosomal proteins, soluble hydrolases as well as membrane proteins, lead to lysosomal storage diseases (LSDs). Lysosomes containing undegraded substrates are finally stacked and therefore miss positioned inside the cell, leading to lysosomal dysfunction, which impacts a wide range of cellular functions.

Original languageEnglish
Pages (from-to)1076-1087
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1865
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019
Externally publishedYes

Keywords

  • Anterograde
  • Dynein
  • Kinesin
  • Lysosomal storage diseases
  • Lysosomes
  • Retrograde

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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