Laminin inhibits amyloid-β-peptide fibrillation

Francisca C. Bronfman, Jorge Garrido, Alejandra Alvarez, Carlos Morgan, Nibaldo C. Inestrosa

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-β-peptide (Aβ) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/Aβ protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit Aβ fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalNeuroscience Letters
Volume218
Issue number3
DOIs
Publication statusPublished - 8 Nov 1996
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid-β-peptide
  • Laminin

ASJC Scopus subject areas

  • Neuroscience(all)

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