Abstract
Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-β-peptide (Aβ) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/Aβ protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit Aβ fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.
Original language | English |
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Pages (from-to) | 201-203 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 218 |
Issue number | 3 |
DOIs | |
Publication status | Published - 8 Nov 1996 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Amyloid-β-peptide
- Laminin
ASJC Scopus subject areas
- General Neuroscience