Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

Lynn E. Delisi, Sarah Shaw, Timothy J. Crow, Gail Shields, Angela B. Smith, Veronica W. Larach, Nigel Wellman, Josephine Loftus, Betsy Nathankumar, Kamran Razi, Maureen Kushner, John Stewart, Antonio Vita, Margherita Comazzi, Robin Sherrington

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number2
DOIs
Publication statusPublished - 3 Apr 2000

Keywords

  • Chromosome 13
  • Chromosome 8
  • Genes
  • Linkage
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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