Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

Lynn E. Delisi; Sarah Shaw; Timothy J. Crow; Gail Shields; Angela B. Smith; Veronica W. Larach; Nigel Wellman; Josephine Loftus; Betsy Nathankumar; Kamran Razi; Maureen Kushner; John Stewart; Antonio Vita; Margherita Comazzi; Robin Sherrington

doi:10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L

Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

Lynn E. Delisi, Sarah Shaw, Timothy J. Crow, Gail Shields, Angela B. Smith, Veronica W. Larach, Nigel Wellman, Josephine Loftus, Betsy Nathankumar, Kamran Razi, Maureen Kushner, John Stewart, Antonio Vita, Margherita Comazzi, Robin Sherrington

Medicine School

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.

Original language	English
Pages (from-to)	235-239
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	96
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L
Publication status	Published - 3 Apr 2000

Keywords

Chromosome 13
Chromosome 8
Genes
Linkage
Schizophrenia

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L

Cite this

Delisi, L. E., Shaw, S., Crow, T. J., Shields, G., Smith, A. B., Larach, V. W., Wellman, N., Loftus, J., Nathankumar, B., Razi, K., Kushner, M., Stewart, J., Vita, A., Comazzi, M., & Sherrington, R. (2000). Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(2), 235-239. https://doi.org/10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L

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abstract = "A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.",

keywords = "Chromosome 13, Chromosome 8, Genes, Linkage, Schizophrenia",

author = "Delisi, {Lynn E.} and Sarah Shaw and Crow, {Timothy J.} and Gail Shields and Smith, {Angela B.} and Larach, {Veronica W.} and Nigel Wellman and Josephine Loftus and Betsy Nathankumar and Kamran Razi and Maureen Kushner and John Stewart and Antonio Vita and Margherita Comazzi and Robin Sherrington",

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language = "English",

volume = "96",

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journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

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Delisi, LE, Shaw, S, Crow, TJ, Shields, G, Smith, AB, Larach, VW, Wellman, N, Loftus, J, Nathankumar, B, Razi, K, Kushner, M, Stewart, J, Vita, A, Comazzi, M & Sherrington, R 2000, 'Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 96, no. 2, pp. 235-239. https://doi.org/10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L

TY - JOUR

T1 - Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

AU - Delisi, Lynn E.

AU - Shaw, Sarah

AU - Crow, Timothy J.

AU - Shields, Gail

AU - Smith, Angela B.

AU - Larach, Veronica W.

AU - Wellman, Nigel

AU - Loftus, Josephine

AU - Nathankumar, Betsy

AU - Razi, Kamran

AU - Kushner, Maureen

AU - Stewart, John

AU - Vita, Antonio

AU - Comazzi, Margherita

AU - Sherrington, Robin

PY - 2000/4/3

Y1 - 2000/4/3

N2 - A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.

AB - A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.

KW - Chromosome 13

KW - Chromosome 8

KW - Genes

KW - Linkage

KW - Schizophrenia

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AN - SCOPUS:0009964816

VL - 96

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JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 2

ER -

Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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