Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer

Claudia Riedel; Orsolya Dohán; Antonio De la Vieja; Christopher S. Ginter; Nancy Carrasco

doi:10.1016/S0968-0004(01)01904-1

Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer

Claudia Riedel
, Orsolya Dohán
, Antonio De la Vieja
, Christopher S. Ginter
, Nancy Carrasco

Life Sciences School

Research output: Contribution to journal › Review article › peer-review

62 Citations (Scopus)

Abstract

The Na⁺/I^- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I^- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na⁺-dependent I^- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

Original language	English
Pages (from-to)	490-496
Number of pages	7
Journal	Trends in Biochemical Sciences
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/S0968-0004(01)01904-1
Publication status	Published - 1 Aug 2001

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(01)01904-1

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title = "Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer",

abstract = "The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.",

author = "Claudia Riedel and Orsolya Doh{\'a}n and \{De la Vieja\}, Antonio and Ginter, \{Christopher S.\} and Nancy Carrasco",

note = "Funding Information: C.R. was supported by the United States ARMY Medical Research and Materiel Command Office Award BC990754. This work was supported by the National Institutes of Health DK-41544 (N.C.).",

year = "2001",

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doi = "10.1016/S0968-0004(01)01904-1",

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T1 - Journey of the iodide transporter NIS

T2 - From its molecular identification to its clinical role in cancer

AU - Riedel, Claudia

AU - Dohán, Orsolya

AU - De la Vieja, Antonio

AU - Ginter, Christopher S.

AU - Carrasco, Nancy

N1 - Funding Information: C.R. was supported by the United States ARMY Medical Research and Materiel Command Office Award BC990754. This work was supported by the National Institutes of Health DK-41544 (N.C.).

PY - 2001/8/1

Y1 - 2001/8/1

N2 - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

AB - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

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U2 - 10.1016/S0968-0004(01)01904-1

DO - 10.1016/S0968-0004(01)01904-1

M3 - Review article

C2 - 11504625

AN - SCOPUS:0035425520

SN - 0968-0004

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EP - 496

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 8

ER -

Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer

Abstract

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