Abstract
The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the α2-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal anti-inflammatory drugs, when coadministered intraperitoneally and intrathecally (i.t.). The simultaneous intraperitoneal administration of fixed ratios of ED50 fractions of all nonsteroidal anti-inflammatory drugs (naproxen, piroxicam, paracetamol, dipyrone or metamizol and nimesulide) combined with clonidine resulted in synergistic interactions. The same combinations administered intrathecally were additive. The synergistic interactions between systemic nonsteroidal anti-inflammatory drugs and clonidine may involve supraspinal mechanisms.
Original language | English |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Pharmacological Research |
Volume | 50 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sept 2004 |
Keywords
- Antinociception
- Clonidine
- Isobolograms
- NSAIDs
- Synergy
ASJC Scopus subject areas
- Pharmacology