Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs

H. F. Miranda, G. Pinardi

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the α2-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal anti-inflammatory drugs, when coadministered intraperitoneally and intrathecally (i.t.). The simultaneous intraperitoneal administration of fixed ratios of ED50 fractions of all nonsteroidal anti-inflammatory drugs (naproxen, piroxicam, paracetamol, dipyrone or metamizol and nimesulide) combined with clonidine resulted in synergistic interactions. The same combinations administered intrathecally were additive. The synergistic interactions between systemic nonsteroidal anti-inflammatory drugs and clonidine may involve supraspinal mechanisms.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalPharmacological Research
Volume50
Issue number3
DOIs
Publication statusPublished - Sept 2004

Keywords

  • Antinociception
  • Clonidine
  • Isobolograms
  • NSAIDs
  • Synergy

ASJC Scopus subject areas

  • Pharmacology

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