TY - JOUR
T1 - Involvement of the insular cortex in retention of conditioned taste aversion is not time dependent
AU - Stehberg, Jimmy
AU - Simon, Felipe
N1 - Funding Information:
A large part of this study was performed at the laboratory of Prof. Yadin Dudai, Weizmann Institute of Science, Israel. We would like to thank Professor Yadin Dudai for his support and funding. Dr. Matthieu Guiton, Nimrod Dorfman for helpful comments and Gonzalo Gamarra for assistance with references. This work was supported by Grants UNAB AR-01-10, UNAB AR-05-09, ICM P04-071-S, UNAB DI-40-09/R and FONDECYT 11080119.
PY - 2011/1
Y1 - 2011/1
N2 - In fear-associated learning paradigms, hippocampal lesions induce memory deficits of recent but not remote memories, while amygdala lesions produce retention deficits irrespective of the age of the memory. In conditioned taste aversion (CTA), non-hippocampal mediated learning paradigm, the insular vortex (IC) has shown to have a crucial role in consolidation and storage of CTA memory. Due to the functional and anatomical similarities to the hippocampus, a time dependent role of the IC in CTA retention cannot be ruled out. To test whether the IC shows a time dependent role in CTA memory retention, male Wistar rats were CTA trained on saccharin 0.1% (LiCl 0.15. M, 2% b/w, 40. min after drinking) and lesioned with ibotenic acid (200-300. nL, 5. mg/mL) unilaterally into the IC 1. week or bilaterally 1 or 6. weeks after CTA. CTA memory was completely disrupted in both bilateral lesion groups but unaffected in the unilateral lesioned group. The resulting preference was comparable to that of the bilaterally IC lesioned animals exposed to the taste for the first time, proving that in these animals a complete amnesic state was achieved. Bilaterally IC lesioned rats showed normal discrimination between preferred (sucrose 5%) and non-preferred (quinone) tastes. Our data indicates that the involvement of the IC in CTA is not time dependent and that CTA memories are stored in each hemisphere separately.
AB - In fear-associated learning paradigms, hippocampal lesions induce memory deficits of recent but not remote memories, while amygdala lesions produce retention deficits irrespective of the age of the memory. In conditioned taste aversion (CTA), non-hippocampal mediated learning paradigm, the insular vortex (IC) has shown to have a crucial role in consolidation and storage of CTA memory. Due to the functional and anatomical similarities to the hippocampus, a time dependent role of the IC in CTA retention cannot be ruled out. To test whether the IC shows a time dependent role in CTA memory retention, male Wistar rats were CTA trained on saccharin 0.1% (LiCl 0.15. M, 2% b/w, 40. min after drinking) and lesioned with ibotenic acid (200-300. nL, 5. mg/mL) unilaterally into the IC 1. week or bilaterally 1 or 6. weeks after CTA. CTA memory was completely disrupted in both bilateral lesion groups but unaffected in the unilateral lesioned group. The resulting preference was comparable to that of the bilaterally IC lesioned animals exposed to the taste for the first time, proving that in these animals a complete amnesic state was achieved. Bilaterally IC lesioned rats showed normal discrimination between preferred (sucrose 5%) and non-preferred (quinone) tastes. Our data indicates that the involvement of the IC in CTA is not time dependent and that CTA memories are stored in each hemisphere separately.
KW - Conditioned taste aversion (CTA)
KW - Insular cortex
KW - Memory retention
KW - Neocortex
KW - Time dependency
UR - http://www.scopus.com/inward/record.url?scp=78651244503&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2010.10.002
DO - 10.1016/j.nlm.2010.10.002
M3 - Article
C2 - 20955809
AN - SCOPUS:78651244503
SN - 1074-7427
VL - 95
SP - 14
EP - 18
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 1
ER -