Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

M. Mollerach, M. Regueira, L. Bonofiglio, R. Callejo, J. Pace, J. L. Di Fabio, S. Hollingshead, D. Briles, M. Tregnaghi, L. Balbi de Aguirre, E. Aprá, M. Vazquez, L. Galanternic, A. Procopio, D. Logarzo, A. Meccia, C. Kremer, C. Perez, N. Cusa, A. Villagra de TrejoM. Lura de Calafell, J. Pierini de Gaite, R. Fabre, M. Bruno, R. Dalamón, N. Diaz, M. Noriega, D. Gomez, C. Candas, S. Kaufman, S. Francioni, J. Barrio, M. Romanazzi, L. Erica, E. Barrientos, A. Littvik, A. Fuster, M. Vallejo, W. Krause, C. Nobile, S. Brasili, S. Manganello, M. Escobar, E. Aguirre, A. Brú, C. Carranza, N. Salazar, V. David

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalEpidemiology and Infection
Volume132
Issue number2
DOIs
Publication statusPublished - 1 Apr 2004

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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