Intraosseous xanthoma of the mandible: A multi-institutional case series with a literature review

José Alcides Almeida de Arruda, Tatiana Fernandes Araújo Almeida, Lucas Guimarães Abreu, Márcio Bruno Figueiredo do Amaral, Ana Lia Anbinder, René Martínez Flores, Michelle Agostini, Mário José Romañach, Tarcília Aparecida Silva, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. Methods: Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S-100. Results: The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13-45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched-out margin (80%). All cases predominantly consisted of CD68-positive and S-100-negative xanthomatous cells. No recurrences were observed after curettage, with a median follow-up of 27 months. Conclusion: Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.

Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalJournal of Oral Pathology and Medicine
Issue number10
Publication statusPublished - 1 Nov 2019


  • intraosseous
  • jaw
  • mandible
  • xanthoma
  • xanthomatosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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