Interventions for the treatment of xerostomia: A randomized controlled clinical trial

Constanza Marín, Laura Díaz-de-Valdés, Catalina Conejeros, René Martinez, Sven Niklander

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Xerostomia or dry mouth sensation corresponds to a common clinical problem that can significantly impair the oral health related quality of life (OHRQoL). Currently, there is a large variety of local agents available for the treatment of xerostomia, but there is a lack robust evidence supporting the use of one treatment over another. We aimed to compare the effectiveness of a 1% malic acid salivary stimulant spray with a 1.33% betaine-based saliva substitute mouthwash in the improvement of xerostomia. Material and Methods: Fifty-one participants with drug induced or idiopathic xerostomia were randomly allocated into three groups, two intervention and one control group (placebo). OHRQoL and severity of xerostomia were assessed with the OHIP-14sp questionnaire and a visual analogue scale (VAS) respectively. Stimulated and non-stimulated salivary flow rates before and after treatments were also measured. Results: All three groups reported a significantly improvement in the dry mouth sensation and non-stimulated salivary flow rates, but only the malic acid spray and the betaine-based mouthwash significantly improved the OHRQoL. There were no significant differences between both intervention groups. Conclusions: This study provides evidence that both tested agents are comparable in improving the dry mouth sensation and OHRQoL of patients with drug induced and idiopathic xerostomia.

Original languageEnglish
Pages (from-to)e104-e111
JournalJournal of Clinical and Experimental Dentistry
Issue number2
Publication statusPublished - 2021


  • betaine
  • dry mouth
  • malic acid
  • oral-health related quality of life
  • Xerostomia

ASJC Scopus subject areas

  • General Dentistry


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