Inhibición de angiogénesis y progresión tumoral por inhibidor selectivo de ciclooxigenasa-2 celecoxib asociado con Ácido (poli láctico co-glicólico) en línea de células tumorales resistentes a quimioterapia

Translated title of the contribution: Angiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (Lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy

Ignacio Roa Henríquez, Mario Cantín, Cristian Vilos, Carlos Rosas, David Lemus

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor model induced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferation in addition to increased apoptosis (P <0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing cell proliferation, the presence of VEGF and promoting apoptosis of multiresistant TA3 tumor cells.

Translated title of the contributionAngiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (Lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy
Original languageSpanish
Pages (from-to)733-739
Number of pages7
JournalInternational Journal of Morphology
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Jun 2017

ASJC Scopus subject areas

  • Anatomy

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