Inflammatory damage on respiratory and nervous systems due to hRSV infection

Karen Bohmwald; Janyra A. Espinoza; Daniela Becerra; Katherine Rivera; Margarita K. Lay; Susan M. Bueno; Claudia A. Riedel; Alexis M. Kalergis

doi:10.1016/j.coi.2015.05.003

Inflammatory damage on respiratory and nervous systems due to hRSV infection

Karen Bohmwald, Janyra A. Espinoza, Daniela Becerra, Katherine Rivera, Margarita K. Lay, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

Life Sciences School

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

The exacerbated inflammatory response elicited by human Respiratory Syncytial Virus (hRSV) in the lungs of infected patients causes a major health burden in the pediatric and elderly population. Since the discovery of hRSV, the exacerbated host immune-inflammatory response triggered by this virus has been extensively studied. In this article, we review the effects on the airways caused by immune cells and cytokines/chemokines secreted during hRSV infection. While molecules such as interferons contribute at controlling viral infection, IL-17 and others produce damage to the hRSV-infected lung. In addition to affecting the airways, hRSV infection can cause significant neurologic abnormalities in the host, such as seizures and encephalopathy. Although the origin of these symptoms remains unclear, studies from patients suffering neurological alteration suggest an involvement of the inflammatory response against hRSV.

Original language	English
Pages (from-to)	14-21
Number of pages	8
Journal	Current Opinion in Immunology
Volume	36
DOIs	https://doi.org/10.1016/j.coi.2015.05.003
Publication status	Published - 1 Oct 2015

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coi.2015.05.003

Cite this

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title = "Inflammatory damage on respiratory and nervous systems due to hRSV infection",

abstract = "The exacerbated inflammatory response elicited by human Respiratory Syncytial Virus (hRSV) in the lungs of infected patients causes a major health burden in the pediatric and elderly population. Since the discovery of hRSV, the exacerbated host immune-inflammatory response triggered by this virus has been extensively studied. In this article, we review the effects on the airways caused by immune cells and cytokines/chemokines secreted during hRSV infection. While molecules such as interferons contribute at controlling viral infection, IL-17 and others produce damage to the hRSV-infected lung. In addition to affecting the airways, hRSV infection can cause significant neurologic abnormalities in the host, such as seizures and encephalopathy. Although the origin of these symptoms remains unclear, studies from patients suffering neurological alteration suggest an involvement of the inflammatory response against hRSV.",

author = "Karen Bohmwald and Espinoza, {Janyra A.} and Daniela Becerra and Katherine Rivera and Lay, {Margarita K.} and Bueno, {Susan M.} and Riedel, {Claudia A.} and Kalergis, {Alexis M.}",

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T1 - Inflammatory damage on respiratory and nervous systems due to hRSV infection

AU - Bohmwald, Karen

AU - Espinoza, Janyra A.

AU - Becerra, Daniela

AU - Rivera, Katherine

AU - Lay, Margarita K.

AU - Bueno, Susan M.

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The exacerbated inflammatory response elicited by human Respiratory Syncytial Virus (hRSV) in the lungs of infected patients causes a major health burden in the pediatric and elderly population. Since the discovery of hRSV, the exacerbated host immune-inflammatory response triggered by this virus has been extensively studied. In this article, we review the effects on the airways caused by immune cells and cytokines/chemokines secreted during hRSV infection. While molecules such as interferons contribute at controlling viral infection, IL-17 and others produce damage to the hRSV-infected lung. In addition to affecting the airways, hRSV infection can cause significant neurologic abnormalities in the host, such as seizures and encephalopathy. Although the origin of these symptoms remains unclear, studies from patients suffering neurological alteration suggest an involvement of the inflammatory response against hRSV.

AB - The exacerbated inflammatory response elicited by human Respiratory Syncytial Virus (hRSV) in the lungs of infected patients causes a major health burden in the pediatric and elderly population. Since the discovery of hRSV, the exacerbated host immune-inflammatory response triggered by this virus has been extensively studied. In this article, we review the effects on the airways caused by immune cells and cytokines/chemokines secreted during hRSV infection. While molecules such as interferons contribute at controlling viral infection, IL-17 and others produce damage to the hRSV-infected lung. In addition to affecting the airways, hRSV infection can cause significant neurologic abnormalities in the host, such as seizures and encephalopathy. Although the origin of these symptoms remains unclear, studies from patients suffering neurological alteration suggest an involvement of the inflammatory response against hRSV.

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

Inflammatory damage on respiratory and nervous systems due to hRSV infection

Abstract

ASJC Scopus subject areas

UN SDGs

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