Induction of peroxisomal fatty acyl-coenzyme A oxidase and total carnitine acetyl-coenzyme A transferase in primary cultures of rat hepatocytes by garlic extracts

Ariel Orellana, Maria E. Kawada, Maria N. Morales, Luis Vargas, Miguel Bronfman

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Garlic has been proposed as a natural hypolipidemic substance. Most hypolipidemic compounds induce peroxisomal proliferation and increase enzyme activities associated with peroxisomal β-oxidation in rat liver. Here we report that garlic methanol-extracts behave as hypolipidemic drugs, increasing the activity of peroxisomal fatty acyl-coenzyme A oxidase and of total carnitine acetyl-coenzyme A transferase in primary cultures of rat hepatocytes. Both enzymes are considered markers associated with increased peroxisomal β-oxidation. As in the case of hypolipidemic peroxisome proliferators, garlic extracts partially prevented the decrease in fatty acyl-coenzyme A oxidase as the culture aged. No changes were observed in the activity of microsomal NADPH cytochrome c reductase or of mitochondrial glutamate dehydrogenase.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalToxicology Letters
Volume60
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • Cultures
  • Garlic
  • Hepatocytes
  • Hypolipidemic
  • Peroxisomes

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

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