Increase of pro-oxidants with no evidence of lipid peroxidation in exhaled breath condensate after a 10-km race in non-athletes

O. F. Araneda, R. Urbina-Stagno, M. Tuesta, D. Haichelis, M. Alvear, M. P. Salazar, C. García

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

It is a well-established fact that exercise increases pro-oxidants and favors oxidative stress; however, this phenomenon has been poorly studied in human lungs. Pro-oxidative generation (H2O2, NO 2 -), lipid peroxidation markers (MDA), and inflammation (pH) in exhaled breath condensate (EBC) have been determined through data from 10 active subjects who ran 10 km; samples were obtained immediately before, at 20, and at 80 min post-exertion. In EBC, the concentration of H 2O2 at 80 min post-exertion was increased. NO2 - concentration showed a tendency to increase at 80 min post-exertion, with no variations in MDA and pH. No variations of NO2 - were found in plasma, while there was an increase of NO 2 - at 80 min post-exertion in the relation between EBC and plasma. NO2 - in EBC did not correlate to plasmatic NO2 -, while it did correlate directly with H 2O2 in EBC, suggesting a localized origin for the exercise-related NO2 - increase in EBC. MDA in plasma did not increase nor correlate with MDA in EBC. In conclusion, high-intensity exercise increases lung-originated pro-oxidants in non-athlete subjects with no evidence of early lipid peroxidation and changes in the pH value in EBC.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalJournal of Physiology and Biochemistry
Volume70
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Exhaled breath condensate
  • Lung inflammation
  • Lung oxidative stress
  • Runners

ASJC Scopus subject areas

  • Physiology
  • Biochemistry

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