TY - JOUR
T1 - Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System
T2 - A Systematic Review and Meta-Analysis
AU - Orellana-Donoso, Mathias
AU - Milos-Brandenberg, Daniel
AU - Benavente-Urtubia, Andoni
AU - Guerra-Loyola, Javier
AU - Bruna-Mejias, Alejandro
AU - Nova-Baeza, Pablo
AU - Becerra-Farfán, Álvaro
AU - Sepulveda-Loyola, Walter
AU - Luque-Bernal, Ricardo Miguel
AU - Valenzuela-Fuenzalida, Juan José
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - Objective: This systematic review analyzes the anatomical variants in the pancreas and its ductal system to report on their association with pancreatic pathologies. Methods: We conducted a search of the MEDLINE, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception to July 2023. The methodological quality was assessed with the Anatomical Quality Assessment (AQUA) tool. Finally, the pooled prevalence was estimated using a random effects model. Results: 55 studies were found that met the eligibility criteria. The overall prevalence of pancreas divisum (PD) was 18% (95% CI = 15–21%). The prevalence of PD associated with pancreatitis was 30% (95% CI = 1–61%). Conclusions: An anatomical variant of the pancreas such as PD may be the cause of bile duct obstruction, resulting in various clinical complications, such as pancreatitis. Hence, knowing this variant is extremely important for surgeons, especially for those who treat the gastroduodenal region.
AB - Objective: This systematic review analyzes the anatomical variants in the pancreas and its ductal system to report on their association with pancreatic pathologies. Methods: We conducted a search of the MEDLINE, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception to July 2023. The methodological quality was assessed with the Anatomical Quality Assessment (AQUA) tool. Finally, the pooled prevalence was estimated using a random effects model. Results: 55 studies were found that met the eligibility criteria. The overall prevalence of pancreas divisum (PD) was 18% (95% CI = 15–21%). The prevalence of PD associated with pancreatitis was 30% (95% CI = 1–61%). Conclusions: An anatomical variant of the pancreas such as PD may be the cause of bile duct obstruction, resulting in various clinical complications, such as pancreatitis. Hence, knowing this variant is extremely important for surgeons, especially for those who treat the gastroduodenal region.
KW - anatomical variations
KW - clinical anatomy
KW - ductal pancreas
KW - pancreatitis
KW - variations anatomical pancreas
UR - http://www.scopus.com/inward/record.url?scp=85169073153&partnerID=8YFLogxK
U2 - 10.3390/life13081710
DO - 10.3390/life13081710
M3 - Review article
AN - SCOPUS:85169073153
SN - 0024-3019
VL - 13
JO - Life
JF - Life
IS - 8
M1 - 1710
ER -