In vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: A neurotheranostic platform for Alzheimer's disease

Francisco Morales-Zavala, Pedro Jara-Guajardo, David Chamorro, Ana L. Riveros, America Chandia-Cristi, Nicole Salgado, Paola Pismante, Ernest Giralt, Macarena Sánchez-Navarro, Eyleen Araya, Rodrigo Vasquez, Gerardo Acosta, Fernando Albericio, Alejandra Alvarez R, Marcelo J. Kogan

Research output: Contribution to journalArticlepeer-review

Abstract

The development and use of nanosystems is an emerging strategy for the diagnosis and treatment of a broad number of diseases, such as Alzheimer's disease (AD). Here, we developed a neurotheranostic nanosystem based on gold nanorods (GNRs) that works as a therapeutic peptide delivery system and can be detected in vivo for microcomputed tomography (micro-CT), being a diagnostic tool. GNRs functionalized with the peptides Ang2 (a shuttle to the Central Nervous System) and D1 (that binds to the Aβ peptide, also inhibiting its aggregation) allowed detecting differences in vivo between wild type and AD mice (APPswe/PSEN1dE9) 15 minutes after a single dose by micro-CT. Moreover, after a recurrent treatment for one month with GNRs-D1/Ang2, we observed a diminution of amyloid load and inflammatory markers in the brain. Thus, this new designed nanosystem exhibits promising properties for neurotheranostics of AD.

Original languageEnglish
Pages (from-to)4178-4190
Number of pages13
JournalBiomaterials Science
Volume9
Issue number11
DOIs
Publication statusPublished - 7 Jun 2021

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

Fingerprint

Dive into the research topics of 'In vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: A neurotheranostic platform for Alzheimer's disease'. Together they form a unique fingerprint.

Cite this