Improving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization

Adrián Rojas, Seyed Ali Sajadian, Carol López-De-Dicastillo, Nedasadat Saadati Ardestani, Gonzalo Aguila, Abolghasem Jouyban

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Supercritical carbon dioxide (SC-CO2)-based approaches have become more popular in recent years as alternative methods for creating micro- or nanosized medicines. Particularly, high drug solubility is required in those techniques using SC-CO2 as a solvent. During the most recent pandemic years, favipiravir and montelukast were two of the most often prescribed medications for the treatment of COVID-19. In this study, ethanol at 1 and 3 mol% was utilized as a cosolvent to increase the solubility of both medicines in SC-CO2 by a static approach using a range of temperatures (308 to 338 K) and pressure (12 to 30 MPa) values. The experimentally determined solubilities of favipiravir and montelukast in SC-CO2 + 3 mol% ethanol showed solubility values up to 33.3 and 24.5 times higher than that obtained for these drugs with only SC-CO2. The highest values were achieved in the pressure of 12 MPa and temperature of 338 K. Last but not least, six density-based semi-empirical models with various adjustable parameters were used to perform the modeling of the solubility of favipiravir and montelukast.

Original languageEnglish
Pages (from-to)34210-34223
Number of pages14
JournalRSC Advances
Volume13
Issue number48
DOIs
Publication statusPublished - 22 Nov 2023

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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