Identification of il-18 and soluble cell adhesion molecules in the gingival crevicular fluid as novel biomarkers of psoriasis

Fernando Valenzuela, Javier Fernández, Constanza Jiménez, Daniela Cavagnola, Juan Felipe Mancilla, Jessica Astorga, Marcela Hernández, Alejandra Fernández

Research output: Contribution to journalArticlepeer-review

Abstract

Psoriasis is a chronic immunoinflammatory skin disease. Although its diagnosis is clinical, differences in the appearance and severity of lesions pose a challenge for clinicians worldwide. The use of accessible biomarkers for psoriasis could aid in the early diagnosis and treatment of the disease. To date, evidence on the analysis of gingival crevicular fluid (GCF) molecules as novel, accessible, and reliable biomarkers for psoriasis is limited. This cross-sectional study compared the GCF levels of IL-18, soluble (s)ICAM-1, and sE-selectin in psoriatic patients (n = 42) and healthy controls (n = 39). Individuals with psoriasis not undergoing treatment and healthy individuals were included independent of periodontal status. GCF samples were collected, and a multiplex bead immunoassay was performed to quantify the levels of the target molecules. Psoriatic patients presented higher concentrations of IL-18 and lower concentrations of sE-selectin compared to controls (p < 0.05). No differences were found in the levels of sICAM-1 between the two groups (p > 0.05). Psoriasis was associated with IL-18 and E-selectin levels regardless of periodontal status, age, and smoking habit (p < 0.05). The areas under the receiver operating characteristic curve (ROC) for IL-18 and sE-selectin were 0.77 and 0.68, respectively. In conclusion, IL-18 and sE-selectin levels in the GCF could be promising biomarker for psoriasis.

Original languageEnglish
Article number1000
JournalLife
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Biomarkers
  • Cell adhesion molecules
  • E-selectin
  • Gingival crevicular fluid
  • Intercellular adhesion molecule-1
  • Interleukin 18
  • Periodontal disease
  • Psoriasis
  • Skin diseases

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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