Host components that modulate the disease caused by hmpv

Nicolás M.S. Gálvez, Catalina A. Andrade, Gaspar A. Pacheco, Jorge A. Soto, Vicente Stranger, Thomas Rivera, Abel E. Vásquez, Alexis M. Kalergis

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Human metapneumovirus (hMPV) is one of the main pathogens responsible for acute respiratory infections in children up to 5 years of age, contributing substantially to health bur-den. The worldwide economic and social impact of this virus is significant and must be addressed. The structural components of hMPV (either proteins or genetic material) can be detected by several receptors expressed by host cells through the engagement of pattern recognition receptors. The recognition of the structural components of hMPV can promote the signaling of the immune response to clear the infection, leading to the activation of several pathways, such as those related to the interferon response. Even so, several intrinsic factors are capable of modulating the immune response or directly inhibiting the replication of hMPV. This article will discuss the current knowledge regarding the innate and adaptive immune response during hMPV infections. Accordingly, the host intrinsic components capable of modulating the immune response and the elements capable of restricting viral replication during hMPV infections will be examined.

Original languageEnglish
Article number519
JournalViruses
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2021
Externally publishedYes

Keywords

  • Adaptive immunity
  • Host factors
  • Human metapneumovirus
  • Innate immunity

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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