Hormonal carcinogenesis in canine mammary cancer: Molecular mechanisms of estradiol involved in malignant progression

Cristian G. Torres, María P. Iturriaga, Pamela Cruz

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Mammary cancer is a frequent neoplasia in female dogs, in which most important risk factors are hormonal. Sexual hormones as estradiol play an important role in mammary carcinogenesis, being able to induce carcinogenic initiation, promotion and progression. However, the molecular mechanisms involved are incompletely understood. Estradiol is synthesized mainly in the ovaries, nevertheless, high concentrations of estradiol and some of its hormonal precursors have also been described in malignant mammary tumor tissue. The mechanisms of action of estradiol include the classic genomic effects that modulate gene transcription, and non-genomic effects, which trigger quick effects after estradiol binds to its specific receptors. These responses modulate various intracellular signaling pathways, triggering post-translational modification of several proteins. This review will discuss the well-known underlying mechanisms associated with the action of estradiol in the malignant progression of canine mammary tumors.

Original languageEnglish
Article number608
Pages (from-to)1-12
Number of pages12
JournalAnimals
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2021
Externally publishedYes

Keywords

  • Canine mammary cancer
  • Estradiol
  • Hormonal carcinogenesis
  • Tumor progression

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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