TY - JOUR
T1 - Histone lysine methylation and chromatin replication
AU - Rivera, Carlos
AU - Gurard-Levin, Zachary A.
AU - Almouzni, Geneviève
AU - Loyola, Alejandra
N1 - Funding Information:
We thank Raphael Margueron and Michel Wassef for critical reading of the manuscript. C.R. is supported by CONICYT fellowship 22121806. The team of G.A. is supported by la Ligue Nationale contre le Cancer (Equipe labellisée Ligue and postdoctoral fellowship to ZGL), the European Commission Network of Excellence EpiGeneSys (HEALTH-F4-2010-257082), ERC Advanced Grant 2009-AdG_20090506 “Eccentric”, the European Commission large-scale integrating project FP7_HEALTH-2010-259743 “MODHEP”, ANR “ChromaTin” ANR-10-BLAN-1326-03, ANR-11-LABX-0044_DEEP and ANR-10-IDEX-0001-02 PSL*, ANR “CHAPINHIB” ANR-12-BSV5-0022-02 and Aviesan-ITMO cancer project “Epigenomics of breast cancer”. The team of A.L. is supported by the grants ANILLO ACT1119 , Basal Project PFB16 , and FONDECYT 1120170.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - In eukaryotic organisms, the replication of the DNA sequence and its organization into chromatin are critical to maintain genome integrity. Chromatin components, such as histone variants and histone post-translational modifications, along with the higher-order chromatin structure, impact several DNA metabolic processes, including replication, transcription, and repair. In this review we focus on lysine methylation and the relationships between this histone mark and chromatin replication. We first describe studies implicating lysine methylation in regulating early steps in the replication process. We then discuss chromatin reassembly following replication fork passage, where the incorporation of a combination of newly synthesized histones and parental histones can impact the inheritance of lysine methylation marks on the daughter strands. Finally, we elaborate on how the inheritance of lysine methylation can impact maintenance of the chromatin landscape, using heterochromatin as a model chromatin domain, and we discuss the potential mechanisms involved in this process. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.
AB - In eukaryotic organisms, the replication of the DNA sequence and its organization into chromatin are critical to maintain genome integrity. Chromatin components, such as histone variants and histone post-translational modifications, along with the higher-order chromatin structure, impact several DNA metabolic processes, including replication, transcription, and repair. In this review we focus on lysine methylation and the relationships between this histone mark and chromatin replication. We first describe studies implicating lysine methylation in regulating early steps in the replication process. We then discuss chromatin reassembly following replication fork passage, where the incorporation of a combination of newly synthesized histones and parental histones can impact the inheritance of lysine methylation marks on the daughter strands. Finally, we elaborate on how the inheritance of lysine methylation can impact maintenance of the chromatin landscape, using heterochromatin as a model chromatin domain, and we discuss the potential mechanisms involved in this process. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.
KW - Chromatin assembly
KW - Epigenetics
KW - Genomic integrity
KW - Heterochromatin
KW - Histones
KW - Post-translational modifications
UR - http://www.scopus.com/inward/record.url?scp=84913533215&partnerID=8YFLogxK
U2 - 10.1016/j.bbagrm.2014.03.009
DO - 10.1016/j.bbagrm.2014.03.009
M3 - Review article
C2 - 24686120
AN - SCOPUS:84913533215
SN - 1874-9399
VL - 1839
SP - 1433
EP - 1439
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 12
ER -