Abstract
An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.
Original language | English |
---|---|
Article number | 968 |
Journal | Molecules |
Volume | 22 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2017 |
Keywords
- Anti-oomycete activity
- Isocordoin
- Oxyalkyl derivates
- Saprolegnia sp.
ASJC Scopus subject areas
- General Medicine
- Organic Chemistry