Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

Beatriz Escobar, Iván Montenegro, Joan Villena, Enrique Werner, Patricio Godoy, Yusser Olguín, Alejandro Madrid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.

Original languageEnglish
Article number968
JournalMolecules
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Anti-oomycete activity
  • Isocordoin
  • Oxyalkyl derivates
  • Saprolegnia sp.

ASJC Scopus subject areas

  • Medicine(all)
  • Organic Chemistry

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    Escobar, B., Montenegro, I., Villena, J., Werner, E., Godoy, P., Olguín, Y., & Madrid, A. (2017). Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules, 22(6), [968]. https://doi.org/10.3390/molecules22060968