Green by design: Convergent synthesis, computational analyses, and activity evaluation of new fxa inhibitors bearing peptide triazole linking units

Diego F. Rodríguez, Francisca Durán-Osorio, Yorley Duarte, Pedro Olivares, Yanina Moglie, Kamal Dua, Flavia C. Zacconi

Research output: Contribution to journalArticlepeer-review

Abstract

Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis (energy efficiency), and copper nanoparticle catalysis, thus featuring Earth-abundant metals. The molecules obtained showed FXa inhibition, with IC50-values as low as 17.2 μM and no associated cytotoxicity in HEK293 and HeLa cells. These results showcase the environmental potential and chemical implications of the applied methodologies for the development of new molecules with pharmacological potential.

Original languageEnglish
Article number33
JournalPharmaceutics
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Click chemistry
  • DOACs
  • Drug discovery
  • FXa inhibitors
  • Green chemistry
  • Microwave synthesis
  • Ullmann-Goldberg reaction

ASJC Scopus subject areas

  • Pharmaceutical Science

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