Glucocorticoid resistance in chronic diseases

Juan M. Rodriguez, Matías Monsalves-Alvarez, Sandra Henriquez, Miguel N. Llanos, Rodrigo Troncoso

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are extensively used to suppress allergic, inflammatory, and immune disorders. Although glucocorticoids are highly effective for therapeutic purposes, some patients chronically treated with glucocorticoids can develop reduced glucocorticoid sensitivity or even resistance, increasing patient vulnerability to exaggerated inflammatory responses. Glucocorticoid resistance can occur in several chronic diseases, including asthma, major depression, and cardiovascular conditions. In this review, we discuss the complexity of the glucocorticoid receptor and the potential role of glucocorticoid resistance in the development of chronic diseases.

Original languageEnglish
Pages (from-to)182-192
Number of pages11
JournalSteroids
Volume115
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Corticosterone
  • Cortisol
  • Glucocorticoid receptor
  • Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Endocrinology
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Rodriguez, J. M., Monsalves-Alvarez, M., Henriquez, S., Llanos, M. N., & Troncoso, R. (2016). Glucocorticoid resistance in chronic diseases. Steroids, 115, 182-192. https://doi.org/10.1016/j.steroids.2016.09.010