Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Translated title of the contribution: Total globulins and lymphocyte count as markers of mortality in sepsis and septic shock

Rodrigo Conlledo, Álvaro Rodríguez, Javiera Godoy, Carlos Merino, Felipe Martínez

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

Original languageSpanish
Pages (from-to)192-199
Number of pages8
JournalRevista Chilena de Infectologia
Volume29
Issue number2
DOIs
Publication statusPublished - 1 Apr 2012

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Globulins
Lymphocyte Count
Septic Shock
Sepsis
Mortality
ROC Curve
Area Under Curve
Intensive Care Units
Hospitalization
Cohort Studies
Prospective Studies
Lymphocytes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Conlledo, Rodrigo ; Rodríguez, Álvaro ; Godoy, Javiera ; Merino, Carlos ; Martínez, Felipe. / Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico. In: Revista Chilena de Infectologia. 2012 ; Vol. 29, No. 2. pp. 192-199.
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Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico. / Conlledo, Rodrigo; Rodríguez, Álvaro; Godoy, Javiera; Merino, Carlos; Martínez, Felipe.

In: Revista Chilena de Infectologia, Vol. 29, No. 2, 01.04.2012, p. 192-199.

Research output: Contribution to journalArticle

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AU - Conlledo, Rodrigo

AU - Rodríguez, Álvaro

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AU - Merino, Carlos

AU - Martínez, Felipe

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