Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Rodrigo Conlledo; Álvaro Rodríguez; Javiera Godoy; Carlos Merino; Felipe Martínez

doi:10.4067/S0716-10182012000200012

Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Translated title of the contribution: Total globulins and lymphocyte count as markers of mortality in sepsis and septic shock

Rodrigo Conlledo, Álvaro Rodríguez, Javiera Godoy, Carlos Merino, Felipe Martínez

Medicine School

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm³, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

Translated title of the contribution	Total globulins and lymphocyte count as markers of mortality in sepsis and septic shock
Original language	Spanish
Pages (from-to)	192-199
Number of pages	8
Journal	Revista Chilena de Infectologia
Volume	29
Issue number	2
DOIs	https://doi.org/10.4067/S0716-10182012000200012
Publication status	Published - 1 Apr 2012

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4067/S0716-10182012000200012

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title = "Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock s{\'e}ptico",

abstract = "Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.",

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T1 - Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

AU - Conlledo, Rodrigo

AU - Rodríguez, Álvaro

AU - Godoy, Javiera

AU - Merino, Carlos

AU - Martínez, Felipe

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

AB - Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

KW - Lymphocytes count

KW - Mortality

KW - Septic shock

KW - Serum globulins

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Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Abstract

ASJC Scopus subject areas

UN SDGs

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