Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Gary S. Stein; Sayyed K. Zaidi; Janet L. Stein; Jane B. Lian; Andre J. Van Wijnen; Martin Montecino; Daniel W. Young; Amjad Javed; Jitesh Pratap; Je Yong Choi; Syed A. Ali; Sandhya Pande; Mohammad Q. Hassan

doi:10.1002/jcb.21813

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Life Sciences School

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

Original language	English
Pages (from-to)	2016-2026
Number of pages	11
Journal	Journal of Cellular Biochemistry
Volume	104
Issue number	6
DOIs	https://doi.org/10.1002/jcb.21813
Publication status	Published - 15 Aug 2008

Keywords

Chromatin
Epigenetic control
Nuclear matrix
Nuclear microenvironments
Transcription

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1002/jcb.21813

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title = "Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer",

abstract = "The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.",

keywords = "Chromatin, Epigenetic control, Nuclear matrix, Nuclear microenvironments, Transcription",

author = "Stein, {Gary S.} and Zaidi, {Sayyed K.} and Stein, {Janet L.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Martin Montecino and Young, {Daniel W.} and Amjad Javed and Jitesh Pratap and Choi, {Je Yong} and Ali, {Syed A.} and Sandhya Pande and Hassan, {Mohammad Q.}",

year = "2008",

month = aug,

day = "15",

doi = "10.1002/jcb.21813",

language = "English",

volume = "104",

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TY - JOUR

T1 - Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

AU - Stein, Gary S.

AU - Zaidi, Sayyed K.

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Montecino, Martin

AU - Young, Daniel W.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Choi, Je Yong

AU - Ali, Syed A.

AU - Pande, Sandhya

AU - Hassan, Mohammad Q.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

AB - The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

KW - Chromatin

KW - Epigenetic control

KW - Nuclear matrix

KW - Nuclear microenvironments

KW - Transcription

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U2 - 10.1002/jcb.21813

DO - 10.1002/jcb.21813

M3 - Article

C2 - 18615590

AN - SCOPUS:49049102076

SN - 0730-2312

VL - 104

SP - 2016

EP - 2026

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

IS - 6

ER -

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Abstract

Keywords

ASJC Scopus subject areas

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