@article{2d0441d78f2b4fc596e9c981dee03468,
title = "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling",
abstract = "Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.",
keywords = "development, metazoan evolution, neural development, neurodevelopmental disorders, protein kinase, protein phosphorylation, signal transduction, stem cells, transcriptomics, ubiquitin signaling",
author = "Francisco Bustos and Anna Segarra-Fas and Gino Nardocci and Andrew Cassidy and Odetta Antico and Lindsay Davidson and Lennart Brandenburg and Macartney, {Thomas J.} and Rachel Toth and Hastie, {C. James} and Jennifer Moran and Robert Gourlay and Joby Varghese and Soares, {Renata F.} and Martin Montecino and Findlay, {Greg M.}",
note = "Funding Information: We thank Nathanael Gray and Tinghu Zhang (Dana-Farber Cancer Institute) for providing SRPKIN-1, Sam Aparicio (University of British Columbia) for CLK-IN-T3, Helen Walden and Viduth Chaugule (University of Glasgow) for fluorescent ubiquitin, and Francisca Cornejo (Universidad Mayor) for hiPSC extracts. We also thank the following colleagues from the University of Dundee: Angus Lamond and Andrea Pawellek for Madrasin, Ron Hay and Emma Branigan for UBE2D1, Miratul Muqit for expertise in mouse neuronal culture, Vicky Cowling and Joana Silva for mouse tissue extracts, Alejandro Brenes for HipSci proteomics data, and Kate Storey for critical reading of the manuscript. G.M.F is supported by a Wellcome Trust /Royal Society Sir Henry Dale fellowship ( 211209/Z/18/Z ) and a Medical Research Council NEW Investigator award (MR/N000609/1). A.S.-F. is supported by a MRC -PPU prize studentship. G.N. and M.M. are supported by research grants ANID /FONDAP/ 15090007 and FONDECYT / 11190998 . Publisher Copyright: {\textcopyright} 2020 The Authors Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
day = "7",
doi = "10.1016/j.devcel.2020.09.025",
language = "English",
volume = "55",
pages = "629--647.e7",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}