Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos, Anna Segarra-Fas, Gino Nardocci, Andrew Cassidy, Odetta Antico, Lindsay Davidson, Lennart Brandenburg, Thomas J. Macartney, Rachel Toth, C. James Hastie, Jennifer Moran, Robert Gourlay, Joby Varghese, Renata F. Soares, Martin Montecino, Greg M. Findlay

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

Original languageEnglish
Pages (from-to)629-647.e7
JournalDevelopmental Cell
Volume55
Issue number5
DOIs
Publication statusPublished - 7 Dec 2020

Keywords

  • development
  • metazoan evolution
  • neural development
  • neurodevelopmental disorders
  • protein kinase
  • protein phosphorylation
  • signal transduction
  • stem cells
  • transcriptomics
  • ubiquitin signaling

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry,Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology

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