TY - JOUR
T1 - Frizzled receptors in neurons
T2 - From growth cones to the synapse
AU - Varela-Nallar, Lorena
AU - Ramirez, Valerie T.
AU - Gonzalez-Billault, Christian
AU - Inestrosa, Nibaldo C.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - The Wnt signaling pathway has been implicated in several different aspects of neural development and function, including dendrite morphogenesis, axonal growth and guidance, synaptogenesis and synaptic plasticity. Here, we studied several Frizzled Wnt receptors and determined their differential expression during hippocampal development. In cultured hippocampal neurons, the cellular distributions of Frizzleds vary greatly, some of them being localized at neurites, growth cones or synaptic sites. These findings suggest that the Wnt signaling pathway might be temporally and spatially fine tuned during the development of neuronal circuits through specific Frizzled receptors.
AB - The Wnt signaling pathway has been implicated in several different aspects of neural development and function, including dendrite morphogenesis, axonal growth and guidance, synaptogenesis and synaptic plasticity. Here, we studied several Frizzled Wnt receptors and determined their differential expression during hippocampal development. In cultured hippocampal neurons, the cellular distributions of Frizzleds vary greatly, some of them being localized at neurites, growth cones or synaptic sites. These findings suggest that the Wnt signaling pathway might be temporally and spatially fine tuned during the development of neuronal circuits through specific Frizzled receptors.
KW - Frizzled receptors
KW - Growth cone
KW - Hippocampal neurons
KW - Synapse
KW - Wnt signaling
UR - http://www.scopus.com/inward/record.url?scp=84863775686&partnerID=8YFLogxK
U2 - 10.1002/cm.21022
DO - 10.1002/cm.21022
M3 - Article
C2 - 22407911
AN - SCOPUS:84863775686
VL - 69
SP - 528
EP - 534
JO - Cell Motility and the Cytoskeleton
JF - Cell Motility and the Cytoskeleton
SN - 1949-3584
IS - 7
ER -