Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria

Francis E. Sluse, Andréa M. Almeida, Wieslawa Jarmuszkiewicz, Anibal E. Vercesi

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Two energy-dissipating systems, an alternative oxidase and an uncoupling protein, are known to exist in plant mitochondria. In tomato fruit mitochondria linoleic acid, a substrate for the uncoupling protein, inhibited the alternative oxidase-sustained respiration and decreased the ADP/O ratio to the same value regardless of the level of alternative oxidase activity. Experiments with varying concentrations of linoleic acid have shown that inhibition of the alternative oxidase is more sensitive to the linoleic acid concentration than the uncoupling protein activation. It can be proposed that these dissipating systems work sequentially during the life of the plant cell, since a high level of free fatty acid-induced uncoupling protein activity excludes alternative oxidase activity.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalFEBS Letters
Volume433
Issue number3
DOIs
Publication statusPublished - 21 Aug 1998

Keywords

  • Alternative oxidase
  • Linoleic acid
  • Lycopersicon esculentum
  • Mitochondrion
  • Plant uncoupling mitochondrial protein

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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